bulkrna-ppi-network

bulkrna-ppi-network is a skill for Claude Code, Codex from TianGzlab/OmicsClaw. It costs 63 tokens per session (1,003 once invoked), scanned A, original, Apache-2.0.

A protein-interaction network analysis for a list of genes that changed between experimental groups. It uses STRING, a public database of known and predicted protein relationships, to build the network.

In plain words
What is it for?
Use it after differential-expression analysis to create interaction-edge and network tables, rank hub genes by the number of connections, and generate network charts and a report.
Why use it?
It shows how the changed genes may be connected and identifies central proteins that could deserve closer attention.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it after differential-expression analysis to create interaction-edge and network tables, rank hub genes by the number of connections, and generate network charts and a report.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/tiangzlab/omicsclaw/bulkrna-ppi-network
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add TianGzlab/OmicsClaw --skill bulkrna-ppi-network
Clone the repo
git clone --depth 1 https://github.com/TianGzlab/OmicsClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for bulkrna-ppi-network

README.md
[![agentmods](https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/bulkrna-ppi-network/github.svg)](https://agentmods.dev/skills/tiangzlab/omicsclaw/bulkrna-ppi-network)
Your own site
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/bulkrna-ppi-network"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/bulkrna-ppi-network/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for bulkrna-ppi-network

Your own site · 80×15
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/bulkrna-ppi-network"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/bulkrna-ppi-network.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 63 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,003 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to high

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • high Rogue Agent · line 3
    Skill modifies its own code, configuration, or behavior at runtime. Self-modification enables an agent to escalate privileges, disable safety constraints, or install persistent backdoors.
    Fix: Prevent the skill from modifying its own code, SKILL.md, or configuration files. Treat skill files as read-only at runtime.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00063 $0.01003
Opus 5 $0.00032 $0.00502
Sonnet 5 $0.00013 $0.00201
Haiku 4.5 $0.00006 $0.00100

Measured 9d ago against content hash 56b33df33779, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-08, from the pricing page.

Security

Grade A, and why

bulkrna-ppi-network scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 9d ago.

The scan reads SKILL.md. This mod also ships 1 executable file (bulkrna_ppi_network.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/bulkrna/bulkrna-ppi-network/SKILL.md · 85 lines

How it starts

The opening of the file, as written. The whole thing — 85 lines — stays where its author put it; the contents beside it link to each section on GitHub.

bulkrna-ppi-network

When to use

Run after bulkrna-de to ask "what does the STRING PPI subgraph induced by my DEG list look like, and which proteins are central?". Queries the public STRING API (no installation needed), constructs the induced subgraph, and ranks hub proteins by degree centrality.

Inputs & Outputs

Inputs

  • File types: .csv, .txt

Outputs

  • tables/hub_genes.csv
  • tables/interaction_edges.csv
  • tables/node_centrality.csv
  • figures/hub_genes_barplot.png
  • figures/ppi_network.png
  • report.md
  • result.json

Flow

  1. Parse gene list from --input (treats first column as gene names).
  2. Query STRING API with species + score_threshold.
  3. On API failure, fall back silently to built-in demo edges (bulkrna_ppi_network.py:118 warns "STRING API failed (...) — using built-in demo edges").
  4. Build NetworkX graph; compute degree centrality.
  5. Report top-N hubs; render network + degree-distribution figures.

Gotchas

  • STRING-API-failure fallback is to DEMO edges, not a smaller real query. bulkrna_ppi_network.py:118 catches any API exception and substitutes the built-in toy network. This means a transient network outage produces output that looks normal but is unrelated to the user's gene list. The summary dict does not record which edge source ran — grep the run's stderr for "STRING API failed" to detect a silent fallback before reporting downstream conclusions.
  • --score-threshold is on STRING's 0–1000 scale, not 0–1. Default 400 is STRING's "medium" confidence band; 700 is "high"; 900 is "highest". Passing 0.4 (a float) is silently coerced to 0 and pulls every edge in the database.
  • --species is the NCBI taxon ID (default 9606 human, 10090 mouse). Passing the string "human" or "mouse" raises a type error from int(args.species). STRING also requires the species to be in its supported list — exotic taxa fail at the API layer.
  • Gene-name namespace must match STRING's expectations. STRING uses HGNC symbols for human, MGI symbols for mouse. Feeding Ensembl IDs gives ~zero hits and a near-empty network — pre-run bulkrna-geneid-mapping to convert.

Read the full file on GitHub · 85 lines

Files

What ships with it

5 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 9d ago First seen · 85 lines · 63 tokens per session scan A 56b33df33779

Subscribe to this mod's changes

bulkrna-ppi-network is a skill published in the GitHub repository TianGzlab/OmicsClaw (160 stars, last pushed 1mo ago), licensed Apache-2.0. It adds 63 tokens to every session and 1,003 once invoked, about $0.0003 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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