ChIP-Atlas Peak Enrichment

ChIP-Atlas Peak Enrichment is a skill for Claude Code, Codex from TianGzlab/OmicsClaw. It costs 7 tokens per session (4,239 once invoked), scanned A, original, Apache-2.0.

A tool that checks whether proteins or DNA-binding factors are found near a submitted list of genes in public ChIP-seq experiments. It uses ChIP-seq, a method for measuring where proteins attach to DNA.

In plain words
What is it for?
Use it to find transcription factors, histone marks, or other chromatin regulators associated with a gene set, including regulators specific to selected cell types.
Why use it?
It helps connect gene lists from expression or pathway analyses to possible regulators without processing raw sequencing reads.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to find transcription factors, histone marks, or other chromatin regulators associated with a gene set, including regulators specific to selected cell types.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/tiangzlab/omicsclaw/chip-atlas-peak-enrichment
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add TianGzlab/OmicsClaw --skill chip-atlas-peak-enrichment
Clone the repo
git clone --depth 1 https://github.com/TianGzlab/OmicsClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for ChIP-Atlas Peak Enrichment

README.md
[![agentmods](https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/chip-atlas-peak-enrichment/github.svg)](https://agentmods.dev/skills/tiangzlab/omicsclaw/chip-atlas-peak-enrichment)
Your own site
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/chip-atlas-peak-enrichment"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/chip-atlas-peak-enrichment/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for ChIP-Atlas Peak Enrichment

Your own site · 80×15
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/chip-atlas-peak-enrichment"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/chip-atlas-peak-enrichment.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 7 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 4,239 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to medium

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • medium analysis-evasion · line 1
    Suspicious Unicode normalization or mixed-script content
    Fix: Review the flagged content for security risks. Ensure no credentials, secrets, or sensitive data are exposed.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00007 $0.04239
Opus 5 $0.00003 $0.02119
Sonnet 5 $0.00001 $0.00848
Haiku 4.5 $0.00001 $0.00424

Measured 12d ago against content hash cdaf0bb200bd, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-11, from the pricing page.

Security

Grade A, and why

ChIP-Atlas Peak Enrichment scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 12d ago.

The scan reads SKILL.md. This mod also ships 9 executable files (scripts/__init__.py, scripts/convert_genes_to_regions.py, scripts/export_all.py, …), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

Origin

Copies of this mod

1 near-identical copy found in the catalogue:

knowledge_base/chip-atlas-peak-enrichment/SKILL.md · 218 lines

How it starts

The opening of the file, as written. The whole thing — 218 lines — stays where its author put it; the contents beside it link to each section on GitHub.

ChIP-Atlas Peak Enrichment

Find ChIP-seq peak enrichment near your genes using the official ChIP-Atlas Enrichment Analysis API.

When to Use This Skill

Use ChIP-Atlas peak enrichment when you need to:

  • Identify transcription factors binding near your genes from DE analysis or pathway results
  • Discover chromatin regulators (TFs, histone modifications, chromatin remodelers) enriched near your gene set
  • Validate regulatory relationships between factors and target genes using public ChIP-seq data
  • Find cell-type-specific regulators by filtering to specific cell classes
  • Query 433,000+ ChIP-seq experiments via the official API without manual downloads

Don't use for:

  • Direct ChIP-seq analysis from raw reads (use peak calling workflows)
  • Single gene lookups (use ChIP-Atlas web interface directly)
  • Offline analysis (requires internet for API calls)

Key Concept: Submits your gene list to the ChIP-Atlas API, which performs Fisher's exact test enrichment analysis against all public ChIP-seq experiments. Returns fold enrichment, P-values, and BH-corrected Q-values.

Installation

Software Version License Commercial Use Installation
pandas >=1.3 BSD-3-Clause Permitted pip install pandas
requests >=2.25 Apache-2.0 Permitted pip install requests
numpy >=1.20 BSD-3-Clause Permitted pip install numpy
plotnine >=0.10 MIT Permitted pip install plotnine
plotnine-prism >=0.3 MIT Permitted pip install plotnine-prism
pip install pandas requests numpy plotnine plotnine-prism

System requirements: Internet connection (API calls to ChIP-Atlas and Ensembl)

Inputs

Gene list:

  • Gene symbols (e.g., ["TP53", "MYC", "EGFR"])
  • Minimum: 3 genes; Recommended: 5-100 genes
  • Formats: Python list, plain text (one per line), CSV with gene column

Parameters:

  • Genome: hg38 (default), hg19, mm10, mm9, rn6, dm6, dm3, ce11, ce10, sacCer3
  • Antigen class: "TFs and others" (default), "Histone", "ATAC-Seq", "DNase-seq", "RNA polymerase"
  • Cell class: "All cell types" (default), "Blood", "Neural", "Breast", etc.
  • Threshold: Peak-calling stringency (MACS2 -10×log10(p)): 50 (default, ~p<1e-5), 100 (~p<1e-10), 200 (~p<1e-20), 500 (~p<1e-50). Higher = fewer, more confident peaks. See references/peak_thresholds.md.
  • TSS window: 5000bp upstream, 5000bp downstream (default)

Read the full file on GitHub · 218 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 12d ago First seen · 218 lines · 7 tokens per session scan A cdaf0bb200bd

Subscribe to this mod's changes

ChIP-Atlas Peak Enrichment is a skill published in the GitHub repository TianGzlab/OmicsClaw (160 stars, last pushed 1mo ago), licensed Apache-2.0. It adds 7 tokens to every session and 4,239 once invoked, about $0.0000 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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