genomics-variant-calling

genomics-variant-calling is a skill for Claude Code, Codex from TianGzlab/OmicsClaw. It costs 89 tokens per session (970 once invoked), scanned A, original, Apache-2.0.

A tool for summarising small DNA variants, such as single-letter changes and short insertions or deletions, from a VCF file. A VCF is a standard file that lists genetic variants found in sequencing data.

In plain words
What is it for?
Use it to count variants, split SNPs from indels, calculate the Ti/Tv ratio, and group variants by chromosome.
Why use it?
It provides common variant counts and distributions without running a separate variant-calling program.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to count variants, split SNPs from indels, calculate the Ti/Tv ratio, and group variants by chromosome.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/tiangzlab/omicsclaw/genomics-variant-calling
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add TianGzlab/OmicsClaw --skill genomics-variant-calling
Clone the repo
git clone --depth 1 https://github.com/TianGzlab/OmicsClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for genomics-variant-calling

README.md
[![agentmods](https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/genomics-variant-calling/github.svg)](https://agentmods.dev/skills/tiangzlab/omicsclaw/genomics-variant-calling)
Your own site
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/genomics-variant-calling"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/genomics-variant-calling/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for genomics-variant-calling

Your own site · 80×15
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/genomics-variant-calling"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/genomics-variant-calling.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 89 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 970 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to high

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • high Rogue Agent · line 3
    Skill modifies its own code, configuration, or behavior at runtime. Self-modification enables an agent to escalate privileges, disable safety constraints, or install persistent backdoors.
    Fix: Prevent the skill from modifying its own code, SKILL.md, or configuration files. Treat skill files as read-only at runtime.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00089 $0.00970
Opus 5.5 $0.00036 $0.00388
Sonnet 5.5 $0.00018 $0.00194
Haiku 4.5 $0.00009 $0.00097

Measured 17d ago against content hash 8c1d32659808, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

genomics-variant-calling scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 17d ago.

The scan reads SKILL.md. This mod also ships 4 executable files (_api.py, examples/example_step.py, genomics_variant_calling.py, …), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/genomics/genomics-variant-calling/SKILL.md · 129 lines

How it starts

The opening of the file, as written. The whole thing — 129 lines — stays where its author put it; the contents beside it link to each section on GitHub.

genomics-variant-calling

When to use

Load this skill for the file-based analysis named in the description. The function library and CLI share the same calculations; no external aligner, assembler, caller or annotation service is started.

Use from a step

from skills._sdk.notebook import load_skill, read_input, write_output
library = load_skill("genomics-variant-calling")
data = read_input("input.vcf", reader=library.read_records)
result = library.analyze(data)
write_output(result, "tables/result.csv")
write_output(library.distribution_figure(result), "figures/distribution.png")

Run examples/example_step.py through the step runner for a small, hand-worked synthetic fixture. It asserts known summary values. The reader materializes the input in memory; use bounded FASTQ reads or pre-filter large genomic files before loading them.

API

read_records(path: str | Path) -> pd.DataFrame

Read records through read_input(path, reader=library.read_records).

:param path: Input file in the format documented under Inputs and outputs.

:returns: Parsed records as a DataFrame. :raises ValueError: Input values or file structure cannot be parsed.

analyze(data: pd.DataFrame) -> pd.DataFrame

Compute variant-calling summaries and return a new table, leaving data unchanged.

:param data: Records containing chrom, pos, ref, alt, qual, filter, type.

:returns: Result table with diagnostics and summary in attrs['run_info']. :raises ValueError: Required columns are absent or records are empty or invalid.

run_info(data: pd.DataFrame, *, keep: bool=True) -> dict

Return analysis diagnostics and summary.

:param data: Result returned by analyze. :param keep: Keep diagnostics by default; the CLI passes False. :returns: Independent diagnostics dictionary. :raises ValueError: analyze has not populated diagnostics.

distribution_figure(data: pd.DataFrame)

Read the full file on GitHub · 129 lines

Files

What ships with it

8 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 17d ago Changed · +37 lines 8c1d32659808
  2. 1mo ago First seen · 92 lines · 89 tokens per session scan A 2fcf4a67773c

Subscribe to this mod's changes

genomics-variant-calling is a skill published in the GitHub repository TianGzlab/OmicsClaw (161 stars, last pushed 17d ago), licensed Apache-2.0. It adds 89 tokens to every session and 970 once invoked, about $0.0004 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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