proteomics-enrichment

proteomics-enrichment is a skill for Claude Code, Codex from TianGzlab/OmicsClaw. It costs 45 tokens per session (1,012 once invoked), scanned A, original, Apache-2.0.

A tool for testing whether a protein list is over-represented in predefined biological pathways. It uses Fisher's exact test and adjusts results for false discoveries, but its pathway list is a small built-in demo rather than a real pathway database.

In plain words
What is it for?
Use it to analyse a CSV of selected proteins and create pathway-enrichment results.
Why use it?
It provides a quick way to see whether proteins of interest cluster in particular example pathways. It is not suitable for production analysis with databases such as KEGG or Reactome.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to analyse a CSV of selected proteins and create pathway-enrichment results.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/tiangzlab/omicsclaw/proteomics-enrichment
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add TianGzlab/OmicsClaw --skill proteomics-enrichment
Clone the repo
git clone --depth 1 https://github.com/TianGzlab/OmicsClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for proteomics-enrichment

README.md
[![agentmods](https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/proteomics-enrichment/github.svg)](https://agentmods.dev/skills/tiangzlab/omicsclaw/proteomics-enrichment)
Your own site
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/proteomics-enrichment"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/proteomics-enrichment/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for proteomics-enrichment

Your own site · 80×15
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/proteomics-enrichment"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/proteomics-enrichment.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 45 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,012 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to high

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • high Rogue Agent · line 3
    Skill modifies its own code, configuration, or behavior at runtime. Self-modification enables an agent to escalate privileges, disable safety constraints, or install persistent backdoors.
    Fix: Prevent the skill from modifying its own code, SKILL.md, or configuration files. Treat skill files as read-only at runtime.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00045 $0.01012
Opus 5.5 $0.00018 $0.00405
Sonnet 5.5 $0.00009 $0.00202
Haiku 4.5 $0.00005 $0.00101

Measured 20d ago against content hash 69498d441bcc, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

proteomics-enrichment scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 20d ago.

The scan reads SKILL.md. This mod also ships 5 executable files (_api.py, examples/example_step.py, prot_enrichment.py, …), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/proteomics/proteomics-enrichment/SKILL.md · 123 lines

How it starts

The opening of the file, as written. The whole thing — 123 lines — stays where its author put it; the contents beside it link to each section on GitHub.

proteomics-enrichment

When to use

ORA uses one-sided Fisher tests and BH correction. Pass an explicit pathway_db and a background_size matching the measured universe. Use existing search-engine tables; this skill does not search raw spectra.

Use from a step

from skills._sdk.notebook import load_skill, write_output
library = load_skill('proteomics-enrichment')
data = library.demo_data(random_state=42)
result = library.enrich(data['protein_id'].tolist(), pathway_db=library.demo_pathways())
write_output(result, 'tables/enrichment_results.csv')

For real data, use read_input and pass any read_table helper as reader=. The executable examples/example_step.py also checks the result and writes a Figure.

API

enrich(genes: list[str], *, pathway_db: dict | None=None, background_size: int | None=None, method: str='ora') -> pd.DataFrame

Run one-sided Fisher tests with BH correction against an explicit pathway library.

:param genes: Protein or gene identifiers in the same identifier space as pathway_db. :param pathway_db: Required pathway-to-member mapping; no default biological database is assumed. :param background_size: CLI default None uses the input/library union plus at least one background-only member. :param method: CLI default ora is the only implemented method. :returns: Ranked pathway overlaps, odds ratios and adjusted p values. :raises ValueError: The library is absent, the method is invalid, or the background is too small.

run_info(table: pd.DataFrame, *, keep: bool=True) -> dict

Read enrichment diagnostics.

:param table: Output of enrich. :param keep: True preserves attrs; False removes diagnostics. :returns: A separate dictionary with library provenance and summary. :raises TypeError: The input is not a DataFrame.

enrichment_figure(table: pd.DataFrame, *, top_n: int=10)

Plot leading pathways by enrichment ratio.

Read the full file on GitHub · 123 lines

Files

What ships with it

8 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 20d ago Changed · +29 lines · -25 tokens per session 69498d441bcc
  2. 1mo ago First seen · 94 lines · 70 tokens per session scan A deb4e65a36b1

Subscribe to this mod's changes

proteomics-enrichment is a skill published in the GitHub repository TianGzlab/OmicsClaw (161 stars, last pushed 20d ago), licensed Apache-2.0. It adds 45 tokens to every session and 1,012 once invoked, about $0.0002 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

Related

Other skills, from other repositories

bio-agent-skills-hub

Discover and invoke 1,676 deduplicated biomedical AI agent skills from the Awesome Bio Agent Skills repository (20 source repos, 15 categories). Use this skill as a router whenever a user needs a bioinformatics/biomedical task (genomics, transcriptomics, single-cell, proteomics, protein design, clinical, epigenomics…

BioTender-max/awesome-bio-agent-skills · 114 tokens

scanpy

Standard single-cell RNA-seq analysis pipeline. Use for QC, normalization, dimensionality reduction (PCA/UMAP/t-SNE), clustering, differential expression, and visualization. Best for exploratory scRNA-seq analysis with established workflows. For deep learning models use scvi-tools; for data format questions use…

synthetic-sciences/openscience · 68 tokens

cellxgene-census-query

Query CZ CELLxGENE Census (61M+ cells). Filter by cell type/tissue/disease, retrieve expression data, and integrate with scanpy/PyTorch for population-scale single-cell analysis. Use this skill when: (1) Querying single-cell expression data by cell type, tissue, or disease, (2) Exploring available single-cell datasets…

PharMolix/OpenBioMed · 105 tokens

single-cell-scrna-seq-analysis-scanpy

Complete single-cell RNA-seq analysis workflow built on Scanpy and AnnData. Use this skill when: (1) Loading diverse single-cell data formats (10X, h5ad, CSV), (2) Performing quality control and filtering, (3) Normalization, dimensionality reduction, and clustering, (4) Marker gene identification and cell type…

PharMolix/OpenBioMed · 85 tokens

single-cell-multi-omics-analysis-scvi

Probabilistic deep learning framework for single-cell multi-omics data analysis. Use this skill when: (1) Analyzing single-cell RNA-seq data with batch correction, (2) Integrating multi-modal data (CITE-seq, ATAC-seq, multi-omics), (3) Performing cell type annotation with scANVI, (4) Spatial transcriptomics…

PharMolix/OpenBioMed · 94 tokens

single-cell

Single-cell analysis pipeline covering scRNA-seq, snRNA-seq, and CyTOF (mass cytometry) — QC, normalization, integration, clustering, annotation, differential expression, trajectory, cell communication, and TF activity inference.

inflexa-ai/inflexa · 50 tokens