Single-Cell Trajectory Inference

Single-Cell Trajectory Inference is a skill for Claude Code, Codex from TianGzlab/OmicsClaw. It costs 7 tokens per session (3,181 once invoked), scanned A, original, Apache-2.0.

A single-cell RNA-seq analysis that orders individual cells along possible changes in cell state, such as development or disease progression. It can also examine branches, cell fates, and RNA velocity, an estimate of change direction from RNA measurements.

In plain words
What is it for?
Use it with preprocessed single-cell data to study pseudotime, branching paths, terminal cell states, changing genes, and fate probabilities.
Why use it?
A list of cell types does not show how one state may lead to another. Trajectory analysis helps describe transitions and the genes associated with them.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it with preprocessed single-cell data to study pseudotime, branching paths, terminal cell states, changing genes, and fate probabilities.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/tiangzlab/omicsclaw/scrna-trajectory-inference
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add TianGzlab/OmicsClaw --skill scrna-trajectory-inference
Clone the repo
git clone --depth 1 https://github.com/TianGzlab/OmicsClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for Single-Cell Trajectory Inference

README.md
[![agentmods](https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/scrna-trajectory-inference/github.svg)](https://agentmods.dev/skills/tiangzlab/omicsclaw/scrna-trajectory-inference)
Your own site
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/scrna-trajectory-inference"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/scrna-trajectory-inference/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for Single-Cell Trajectory Inference

Your own site · 80×15
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/scrna-trajectory-inference"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/scrna-trajectory-inference.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 7 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 3,181 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector pass 7 Sept 2026
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00007 $0.03181
Opus 5 $0.00003 $0.01590
Sonnet 5 $0.00001 $0.00636
Haiku 4.5 $0.00001 $0.00318

Measured 10d ago against content hash ec4e1bf4c7b6, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-09, from the pricing page.

Security

Grade A, and why

Single-Cell Trajectory Inference scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 10d ago.

The scan reads SKILL.md. This mod also ships 5 executable files (scripts/export_results.py, scripts/generate_all_plots.py, scripts/generate_report.py, …), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

knowledge_base/scrna-trajectory-inference/SKILL.md · 256 lines

How it starts

The opening of the file, as written. The whole thing — 256 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Single-Cell Trajectory Inference

When to Use This Skill

Use when you have preprocessed scRNA-seq data and want to:

  • ✅ Order cells along a differentiation or disease trajectory (pseudotime)
  • ✅ Identify branching points and terminal cell fates
  • ✅ Discover genes driving cell state transitions
  • ✅ Visualize RNA velocity (direction of cell state change)
  • ✅ Compute cell fate probabilities with CellRank
  • ✅ Chain from scrnaseq-scanpy-core-analysis output

Do NOT use when:

  • ❌ Data is not yet preprocessed (use scrnaseq-scanpy-core-analysis first)
  • ❌ You have bulk RNA-seq (use disease-progression-longitudinal instead)
  • ❌ Cells are terminally differentiated with no trajectory (e.g., resting PBMCs)
  • ❌ Fewer than 200 cells

Installation

pip install scanpy anndata scvelo cellrank numpy pandas matplotlib seaborn scipy statsmodels reportlab
Package Version License Commercial Use Notes
scanpy ≥1.9 BSD-3 ✅ Permitted Core trajectory (PAGA, DPT)
anndata ≥0.8 BSD-3 ✅ Permitted Data container
scvelo ≥0.2.5 BSD-3 ✅ Permitted RNA velocity (optional but recommended)
cellrank ≥2.0 BSD-3 ✅ Permitted Fate mapping (optional)
matplotlib ≥3.4 PSF ✅ Permitted Plotting
seaborn ≥0.11 BSD-3 ✅ Permitted Statistical plotting, heatmaps
scipy ≥1.7 BSD-3 ✅ Permitted Statistics
statsmodels ≥0.13 BSD-3 ✅ Permitted FDR correction
reportlab ≥3.6 BSD ✅ Permitted PDF report (optional)

Graceful degradation: Core analysis (PAGA + pseudotime) requires only scanpy. scVelo and CellRank are optional — scripts detect availability and skip gracefully.

Inputs

Required:

  • Preprocessed AnnData (.h5ad) with PCA, UMAP, and cluster annotations
    • Output from scrnaseq-scanpy-core-analysis (adata_processed.h5ad) works directly
    • Must have ≥200 cells, ≥100 genes, cluster labels in .obs

Read the full file on GitHub · 256 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 10d ago First seen · 256 lines · 7 tokens per session scan A ec4e1bf4c7b6

Subscribe to this mod's changes

Single-Cell Trajectory Inference is a skill published in the GitHub repository TianGzlab/OmicsClaw (160 stars, last pushed 1mo ago), licensed Apache-2.0. It adds 7 tokens to every session and 3,181 once invoked, about $0.0000 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

Related

Other skills, from other repositories

cellxgene-census-query

Query CZ CELLxGENE Census (61M+ cells). Filter by cell type/tissue/disease, retrieve expression data, and integrate with scanpy/PyTorch for population-scale single-cell analysis. Use this skill when: (1) Querying single-cell expression data by cell type, tissue, or disease, (2) Exploring available single-cell datasets…

PharMolix/OpenBioMed · 105 tokens

single-cell-scrna-seq-analysis-scanpy

Complete single-cell RNA-seq analysis workflow built on Scanpy and AnnData. Use this skill when: (1) Loading diverse single-cell data formats (10X, h5ad, CSV), (2) Performing quality control and filtering, (3) Normalization, dimensionality reduction, and clustering, (4) Marker gene identification and cell type…

PharMolix/OpenBioMed · 85 tokens

bio-agent-skills-hub

Discover and invoke 1,676 deduplicated biomedical AI agent skills from the Awesome Bio Agent Skills repository (20 source repos, 15 categories). Use this skill as a router whenever a user needs a bioinformatics/biomedical task (genomics, transcriptomics, single-cell, proteomics, protein design, clinical, epigenomics…

BioTender-max/awesome-bio-agent-skills · 114 tokens

scanpy

Standard single-cell RNA-seq analysis pipeline. Use for QC, normalization, dimensionality reduction (PCA/UMAP/t-SNE), clustering, differential expression, and visualization. Best for exploratory scRNA-seq analysis with established workflows. For deep learning models use scvi-tools; for data format questions use…

synthetic-sciences/openscience · 68 tokens

single-cell-multi-omics-analysis-scvi

Probabilistic deep learning framework for single-cell multi-omics data analysis. Use this skill when: (1) Analyzing single-cell RNA-seq data with batch correction, (2) Integrating multi-modal data (CITE-seq, ATAC-seq, multi-omics), (3) Performing cell type annotation with scANVI, (4) Spatial transcriptomics…

PharMolix/OpenBioMed · 94 tokens

decoupler

Use for any task involving the decoupler library — inferring biological activity/enrichment scores from omics data (bulk, single-cell, spatial). Triggers on estimating transcription factor (TF) activity, pathway activity, or gene-set enrichment from an AnnData/DataFrame; running ulm, mlm, ora, gsea, gsva, aucell…

scverse/decoupler · 220 tokens