spatial-raw-processing

spatial-raw-processing is a skill for Claude Code, Codex from TianGzlab/OmicsClaw. It costs 70 tokens per session (1,850 once invoked), scanned A, original, Apache-2.0.

A processing tool that converts paired-end FASTQ sequencing files into a count matrix for spatial transcriptomics. FASTQ files contain the raw sequencing reads, including spatial barcodes, UMIs, and gene sequences.

In plain words
What is it for?
Use it with Visium or Slide-seq FASTQ files and a STAR genome index to create a raw-counts AnnData file, then run spatial preprocessing.
Why use it?
It turns raw sequencing output into a file that later quality control and analysis steps can use.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it with Visium or Slide-seq FASTQ files and a STAR genome index to create a raw-counts AnnData file, then run spatial preprocessing.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/tiangzlab/omicsclaw/spatial-raw-processing
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add TianGzlab/OmicsClaw --skill spatial-raw-processing
Clone the repo
git clone --depth 1 https://github.com/TianGzlab/OmicsClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for spatial-raw-processing

README.md
[![agentmods](https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/spatial-raw-processing/github.svg)](https://agentmods.dev/skills/tiangzlab/omicsclaw/spatial-raw-processing)
Your own site
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/spatial-raw-processing"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/spatial-raw-processing/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for spatial-raw-processing

Your own site · 80×15
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/spatial-raw-processing"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/spatial-raw-processing.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 70 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 1,850 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to high

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • high Rogue Agent · line 3
    Skill modifies its own code, configuration, or behavior at runtime. Self-modification enables an agent to escalate privileges, disable safety constraints, or install persistent backdoors.
    Fix: Prevent the skill from modifying its own code, SKILL.md, or configuration files. Treat skill files as read-only at runtime.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00070 $0.01850
Opus 5.5 $0.00028 $0.00740
Sonnet 5.5 $0.00014 $0.00370
Haiku 4.5 $0.00007 $0.00185

Measured 14d ago against content hash d488961b1d27, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

spatial-raw-processing scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 14d ago.

The scan reads SKILL.md. This mod also ships 3 executable files (examples/example_step.py, spatial_raw_processing.py, tests/test_spatial_raw_processing.py), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/spatial/spatial-raw-processing/SKILL.md · 142 lines

How it starts

The opening of the file, as written. The whole thing — 142 lines — stays where its author put it; the contents beside it link to each section on GitHub.

spatial-raw-processing

Use from a step

This is CLI_ONLY: ST-Pipeline consumes FASTQ files, barcode coordinates and reference indexes. It is not an in-memory analysis function.

from skills._sdk.notebook import run_cli

output = run_cli("spatial-raw-processing", "--input", "data/run_bundle.json",
                 inputs=["data/run_bundle.json", "data/R1.fastq.gz",
                         "data/R2.fastq.gz", "data/barcodes.tsv"])

Record the reference index version in the module README. The executable example uses synthetic upstream outputs and does not run ST-Pipeline.

When to use

The user has paired-end spatial-transcriptomics FASTQ files (read1 = spatial barcode + UMI, read2 = cDNA) plus a STAR genome index, and wants the standard ST-Pipeline run that produces a raw_counts.h5ad with one row per spatial spot. Single backend: st_pipeline (calls run_stpipeline from skills/spatial/_lib/stpipeline_adapter.py).

After this skill, chain to spatial-preprocess for QC + normalisation. For non-spatial scRNA FASTQ use sc-fastq-qc. For bulk RNA-seq read QC use bulkrna-read-qc.

Inputs & Outputs

Inputs

  • Input kinds: file, directory
  • Modalities: visium, slideseq
  • File types: .fastq, .fq, .json, .yaml, .yml
  • FASTQ structure: valid first record; paired layout
  • Directory layouts (any): paired-fastq

Outputs

  • tables/gene_qc.csv
  • tables/raw_gene_qc.csv
  • tables/raw_processing_run_summary.csv
  • tables/raw_processing_spatial_points.csv
  • tables/raw_spot_qc.csv
  • tables/raw_top_genes.csv
  • tables/run_summary.csv
  • tables/saturation_curve.csv
  • tables/spatial_coordinates.csv
  • tables/spot_qc.csv
  • tables/stage_summary.csv
  • tables/top_genes.csv
  • figures/raw_detected_genes_spatial.png
  • figures/raw_spot_qc_histograms.png
  • figures/raw_top_genes_barplot.png
  • figures/raw_total_counts_spatial.png
  • figures/st_pipeline_saturation_curve.png
  • figures/st_pipeline_stage_attrition.png
  • omicsclaw_stpipeline_run.json
  • raw_counts.h5ad
  • st_pipeline.stderr.txt
  • st_pipeline.stdout.txt
  • report.md
  • result.json
  • Processed AnnData (saves_h5ad) — adds obs: barcode, x_array, y_array; obsm: spatial

Read the full file on GitHub · 142 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 14d ago Changed · +7 lines d488961b1d27
  2. 1mo ago First seen · 135 lines · 70 tokens per session scan A 09724602929f

Subscribe to this mod's changes

spatial-raw-processing is a skill published in the GitHub repository TianGzlab/OmicsClaw (161 stars, last pushed 14d ago), licensed Apache-2.0. It adds 70 tokens to every session and 1,850 once invoked, about $0.0003 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-03.

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