Borrowing it
Nothing to install: this file belongs to 45ck/open-genome-agent. Take a copy, put it at the same path in your own repository, and replace the rules that are about this project with yours.
curl -O https://raw.githubusercontent.com/45ck/open-genome-agent/main/.agents/skills/polygenic-risk/SKILL.mdgit clone --depth 1 https://github.com/45ck/open-genome-agentWrote this? Show the measurements
A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.
[](https://agentmods.dev/skills/45ck/open-genome-agent/polygenic-risk)<a href="https://agentmods.dev/skills/45ck/open-genome-agent/polygenic-risk"><img src="https://agentmods.dev/badge/skills/45ck/open-genome-agent/polygenic-risk/github.svg" alt="Measured on agentmods" height="20"></a>Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.
<a href="https://agentmods.dev/skills/45ck/open-genome-agent/polygenic-risk"><img src="https://agentmods.dev/badge/skills/45ck/open-genome-agent/polygenic-risk.svg" alt="Reviewed on agentmods" width="80" height="20"></a>What it costs to keep this loaded
Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.
| Model | Per session | Once invoked |
|---|---|---|
| Fable 5.1 | $0.00034 | $0.00265 |
| Opus 5.5 | $0.00014 | $0.00106 |
| Sonnet 5.5 | $0.00007 | $0.00053 |
| Haiku 4.5 | $0.00003 | $0.00026 |
Grade A, and why
polygenic-risk scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 2mo ago.
A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.
Nothing flagged
None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.
What it actually says
Polygenic risk
Run optional polygenic or trait-style scoring workflows and label all outputs as probabilistic. Use only when requested and keep results separate from direct variant findings.
When to use
- the user explicitly requests PRS or broad predisposition scoring
Do not use when
- the user expects diagnosis-like certainty
- the toolchain or reference score set is not available
Expected outputs
prs_scores.jsonprs_notes.md
Goal
Run optional PRS-style analysis without letting probabilistic signals look clinical.
Procedure
- Confirm that the user explicitly wants this class of output.
- Record which score set or method was used.
- Present results as relative or exploratory signals only.
- Keep PRS outputs in their own file and summary block.
Guardrails
- Never merge PRS output into
verifiedfindings. - Never present a timeline or certainty.
- If score portability is unclear, say so explicitly.
References
See references/README.md for durable notes and scripts/ for deterministic helpers.
What ships with it
2 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.
What this file has done since we first saw it
Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.
- 2mo ago First seen · 42 lines · 34 tokens per session scan A da9a497c4069
polygenic-risk is a skill published in the GitHub repository 45ck/open-genome-agent (4 stars, last pushed 4mo ago), licensed MIT. It adds 34 tokens to every session and 265 once invoked, about $0.0001 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-31.
Other skills, from other repositories
biomcp-research
Do biomedical literature and variant research with the BioMCP CLI, and file what you learn about the tool itself as issues in the biomcp repo.
genomics-cnv-calling
Load when calling CNV segments via CBS-style segmentation on a bin-level log2-ratio CSV from exome / WGS coverage — emits per-segment 5-class CN state (amplification / gain / neutral / loss / deepdeletion), per-chromosome summary, genome-fraction-altered. Skip when working with single-cell / spatial CNV (use…
genomics-epigenomics
Load when summarising a peak file (BED / narrowPeak) from ATAC-seq / ChIP-seq / CUT&Tag — peak count, width distribution, per-chromosome counts, score statistics. Skip when calling peaks from BAM (run MACS / Genrich externally first); working with single-cell ATAC (use scatac-preprocessing).
genomics-phasing
Load when summarising a phased VCF (output of WhatsHap / SHAPEIT5 / Eagle2) — phased fraction of het variants, phase-block N50, PS-field parsing, pipe-delimited genotype detection. Skip when the input is unphased (run a phaser first); calling small variants (use genomics-variant-calling).
genomics-qc
Load when running pre-alignment FASTQ quality control — Phred quality scores, Q20/Q30 rates, GC / N content, read-length distribution, adapter-contamination detection. Skip when working with already-aligned BAMs (use genomics-alignment); peak / variant files are the input (use the relevant downstream skill).
genomics-alignment
Load when computing alignment QC metrics (mapping rate, MAPQ distribution, insert size, duplicate rate, proper-pair rate) from a text SAM file produced by any short-/long-read aligner (BWA / Bowtie2 / Minimap2); convert a BAM with samtools view -h first. Skip when running the alignment step itself; only FASTQ-level QC…