Borrowing it
Nothing to install: this file belongs to 45ck/open-genome-agent. Take a copy, put it at the same path in your own repository, and replace the rules that are about this project with yours.
curl -O https://raw.githubusercontent.com/45ck/open-genome-agent/main/.agents/skills/polygenic-risk/SKILL.mdgit clone --depth 1 https://github.com/45ck/open-genome-agentWrote this? Show the measurements
A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.
[](https://agentmods.dev/skills/45ck/open-genome-agent/polygenic-risk)<a href="https://agentmods.dev/skills/45ck/open-genome-agent/polygenic-risk"><img src="https://agentmods.dev/badge/skills/45ck/open-genome-agent/polygenic-risk/github.svg" alt="Measured on agentmods" height="20"></a>Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.
<a href="https://agentmods.dev/skills/45ck/open-genome-agent/polygenic-risk"><img src="https://agentmods.dev/badge/skills/45ck/open-genome-agent/polygenic-risk.svg" alt="Reviewed on agentmods" width="80" height="20"></a>What it costs to keep this loaded
Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.
| Model | Per session | Once invoked |
|---|---|---|
| Fable 5.1 | $0.00034 | $0.00265 |
| Opus 5 | $0.00017 | $0.00133 |
| Sonnet 5 | $0.00007 | $0.00053 |
| Haiku 4.5 | $0.00003 | $0.00026 |
Grade A, and why
polygenic-risk scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 8d ago.
A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.
Nothing flagged
None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.
What it actually says
Polygenic risk
Run optional polygenic or trait-style scoring workflows and label all outputs as probabilistic. Use only when requested and keep results separate from direct variant findings.
When to use
- the user explicitly requests PRS or broad predisposition scoring
Do not use when
- the user expects diagnosis-like certainty
- the toolchain or reference score set is not available
Expected outputs
prs_scores.jsonprs_notes.md
Goal
Run optional PRS-style analysis without letting probabilistic signals look clinical.
Procedure
- Confirm that the user explicitly wants this class of output.
- Record which score set or method was used.
- Present results as relative or exploratory signals only.
- Keep PRS outputs in their own file and summary block.
Guardrails
- Never merge PRS output into
verifiedfindings. - Never present a timeline or certainty.
- If score portability is unclear, say so explicitly.
References
See references/README.md for durable notes and scripts/ for deterministic helpers.
What ships with it
2 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.
What this file has done since we first saw it
Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.
- 8d ago First seen · 42 lines · 34 tokens per session scan A da9a497c4069
polygenic-risk is a skill published in the GitHub repository 45ck/open-genome-agent (4 stars, last pushed 2mo ago), licensed MIT. It adds 34 tokens to every session and 265 once invoked, about $0.0002 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-31.
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