genomics-qc

genomics-qc is a skill for Claude Code, Codex from TianGzlab/OmicsClaw. It costs 71 tokens per session (982 once invoked), scanned A, original, Apache-2.0.

A quality-control tool for FASTQ files, which store raw DNA or RNA sequencing reads and their per-base quality scores. It measures read quality, length, GC and unknown-base content, adapter contamination, and per-position quality.

In plain words
What is it for?
Use it before genome or transcriptome alignment to create quality tables, read-length distributions, per-base profiles, a report, and a result file.
Why use it?
It summarizes the condition of raw sequencing data before alignment, without changing or filtering the reads.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it before genome or transcriptome alignment to create quality tables, read-length distributions, per-base profiles, a report, and a result file.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/tiangzlab/omicsclaw/genomics-qc
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add TianGzlab/OmicsClaw --skill genomics-qc
Clone the repo
git clone --depth 1 https://github.com/TianGzlab/OmicsClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for genomics-qc

README.md
[![agentmods](https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/genomics-qc/github.svg)](https://agentmods.dev/skills/tiangzlab/omicsclaw/genomics-qc)
Your own site
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/genomics-qc"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/genomics-qc/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for genomics-qc

Your own site · 80×15
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/genomics-qc"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/genomics-qc.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 71 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 982 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 2 findings, up to high

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • high Rogue Agent · line 3
    Skill modifies its own code, configuration, or behavior at runtime. Self-modification enables an agent to escalate privileges, disable safety constraints, or install persistent backdoors.
    Fix: Prevent the skill from modifying its own code, SKILL.md, or configuration files. Treat skill files as read-only at runtime.
  • medium Output Handling · line 65
    Output size or generation rate is not bounded. Unbounded output enables denial-of-service through resource exhaustion, log flooding, or context-window stuffing.
    Fix: Set explicit limits on output length, generation count, and rate. Use max_tokens and truncation to prevent unbounded output.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00071 $0.00982
Opus 5.5 $0.00028 $0.00393
Sonnet 5.5 $0.00014 $0.00196
Haiku 4.5 $0.00007 $0.00098

Measured 17d ago against content hash ce39beb58b4a, method: parsed. Prices are Anthropic first-party input rates as of 2026-10-07, from the pricing page.

Security

Grade A, and why

genomics-qc scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 17d ago.

The scan reads SKILL.md. This mod also ships 4 executable files (_api.py, examples/example_step.py, genomics_qc.py, …), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/genomics/genomics-qc/SKILL.md · 128 lines

How it starts

The opening of the file, as written. The whole thing — 128 lines — stays where its author put it; the contents beside it link to each section on GitHub.

genomics-qc

When to use

Load this skill for the file-based analysis named in the description. The function library and CLI share the same calculations; no external aligner, assembler, caller or annotation service is started.

Use from a step

from skills._sdk.notebook import load_skill, read_input, write_output
library = load_skill("genomics-qc")
data = read_input("input.fastq", reader=library.read_records)
result = library.analyze(data)
write_output(result, "tables/result.csv")
write_output(library.distribution_figure(result), "figures/distribution.png")

Run examples/example_step.py through the step runner for a small, hand-worked synthetic fixture. It asserts known summary values. The reader materializes the input in memory; use bounded FASTQ reads or pre-filter large genomic files before loading them.

API

read_records(path: str | Path, *, max_reads: int=500000) -> pd.DataFrame

Read records through read_input(path, reader=library.read_records).

:param path: Input file in the format documented under Inputs and outputs. :param max_reads: CLI default 500000 limits records materialized in memory. :returns: Parsed records as a DataFrame. :raises ValueError: Input values or file structure cannot be parsed.

analyze(data: pd.DataFrame, *, max_reads: int=500000) -> pd.DataFrame

Compute qc summaries and return a new table, leaving data unchanged.

:param data: Records containing sequence, quality. :param max_reads: CLI default 500000 limits the analyzed reads. :returns: Result table with diagnostics and summary in attrs['run_info']. :raises ValueError: Required columns are absent or records are empty or invalid.

run_info(data: pd.DataFrame, *, keep: bool=True) -> dict

Return analysis diagnostics and summary.

:param data: Result returned by analyze. :param keep: Keep diagnostics by default; the CLI passes False. :returns: Independent diagnostics dictionary. :raises ValueError: analyze has not populated diagnostics.

Read the full file on GitHub · 128 lines

Files

What ships with it

8 files beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 17d ago Changed · +41 lines ce39beb58b4a
  2. 1mo ago First seen · 87 lines · 71 tokens per session scan A 1c225dda8234

Subscribe to this mod's changes

genomics-qc is a skill published in the GitHub repository TianGzlab/OmicsClaw (161 stars, last pushed 17d ago), licensed Apache-2.0. It adds 71 tokens to every session and 982 once invoked, about $0.0003 per session on Opus 5.5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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