translational-safety

translational-safety is a skill for Claude Code, Codex from inflexa-ai/inflexa. It costs 33 tokens per session (3,040 once invoked), scanned A, original, Apache-2.0.

A guide to assessing drug safety in biomedical research. It covers adverse-event severity, organ toxicity markers, drug-interaction risks, and whether a drug or another cause is responsible for a harmful finding.

In plain words
What is it for?
Use it to grade adverse events, assess liver and kidney toxicity, review drug-metabolism interactions, and investigate possible drug-induced harm.
Why use it?
It provides structured checks for interpreting safety signals and grading the seriousness of possible toxicity.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Use it to grade adverse events, assess liver and kidney toxicity, review drug-metabolism interactions, and investigate possible drug-induced harm.

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Install with agentmods
npx agentmods add skills/inflexa-ai/inflexa/translational-safety
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add inflexa-ai/inflexa --skill translational-safety
Clone the repo
git clone --depth 1 https://github.com/inflexa-ai/inflexa

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for translational-safety

README.md
[![agentmods](https://agentmods.dev/badge/skills/inflexa-ai/inflexa/translational-safety/github.svg)](https://agentmods.dev/skills/inflexa-ai/inflexa/translational-safety)
Your own site
<a href="https://agentmods.dev/skills/inflexa-ai/inflexa/translational-safety"><img src="https://agentmods.dev/badge/skills/inflexa-ai/inflexa/translational-safety/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for translational-safety

Your own site · 80×15
<a href="https://agentmods.dev/skills/inflexa-ai/inflexa/translational-safety"><img src="https://agentmods.dev/badge/skills/inflexa-ai/inflexa/translational-safety.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 33 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 3,040 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe.
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00033 $0.03040
Opus 5 $0.00016 $0.01520
Sonnet 5 $0.00007 $0.00608
Haiku 4.5 $0.00003 $0.00304

Measured 2d ago against content hash 867ed7ffb74b, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-11, from the pricing page.

Security

Grade A, and why

translational-safety scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 2d ago.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

skills/translational-safety/SKILL.md · 256 lines

How it starts

The opening of the file, as written. The whole thing — 256 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Translational Safety

This skill guides safety assessment for translational medicine, covering computational toxicology, safety biomarker interpretation, and adverse event classification.

CTCAE v5 Grading (Common Terminology Criteria for Adverse Events)

When clinical or laboratory safety data includes adverse event severity, use CTCAE v5 grading:

Grade Description Clinical Action
1 Mild; asymptomatic or mild symptoms Observation only
2 Moderate; minimal intervention indicated Outpatient management
3 Severe; hospitalization indicated Dose modification/interruption
4 Life-threatening Urgent intervention
5 Death related to AE

When grading lab values:

Hepatotoxicity (Drug-Induced Liver Injury)

  • ALT/AST: Grade 1: >ULN–3x ULN, Grade 2: 3–5x ULN, Grade 3: 5–20x ULN, Grade 4: >20x ULN
  • Total bilirubin: Grade 1: >ULN–1.5x ULN, Grade 2: 1.5–3x ULN, Grade 3: 3–10x ULN, Grade 4: >10x ULN
  • Hy's Law: ALT >3x ULN AND bilirubin >2x ULN (without ALP >2x ULN) — high risk of fatal DILI
  • RUCAM score: Use to assess causality (drug vs other cause)

Nephrotoxicity

  • Creatinine: Grade 1: >ULN–1.5x baseline, Grade 2: 1.5–3x baseline, Grade 3: 3–6x baseline, Grade 4: >6x baseline
  • eGFR: Monitor trend; acute decline >25% is concerning
  • Proteinuria: Grade 1: +1, Grade 2: +2–3, Grade 3: nephrotic range

Cardiotoxicity

  • Troponin: Any elevation above ULN warrants investigation
  • LVEF: Grade 1: asymptomatic decline, Grade 2: <50% or decline >10%, Grade 3: symptomatic CHF
  • QTc prolongation: Grade 1: 450–480ms, Grade 2: 481–500ms, Grade 3: >500ms or >60ms increase

Hematological Toxicity

  • Neutrophils: Grade 1: <LLN–1500, Grade 2: 1000–1500, Grade 3: 500–1000, Grade 4: <500
  • Platelets: Grade 1: <LLN–75000, Grade 2: 50000–75000, Grade 3: 25000–50000, Grade 4: <25000

Safety Target Panel Quick Lookup

A curated secondary-pharmacology off-target safety panel (~30 well-established liability targets, organ-tagged) is available to you. Use it as a fast first-pass screen before reaching for live tools.

Read the full file on GitHub · 256 lines

Files

What ships with it

1 file beside SKILL.md in the same directory: the scripts, references and assets a skill reads on demand. Not counted in the per-session cost; read them before you install if any of them is executable.

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 2d ago First seen · 256 lines · 33 tokens per session scan A 867ed7ffb74b

Subscribe to this mod's changes

translational-safety is a skill published in the GitHub repository inflexa-ai/inflexa (33 stars, last pushed yesterday), licensed Apache-2.0. It adds 33 tokens to every session and 3,040 once invoked, about $0.0002 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-09-09.

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