Single-Cell RNA-seq Core Analysis (Scanpy)

Single-Cell RNA-seq Core Analysis (Scanpy) is a skill for Claude Code, Codex from TianGzlab/OmicsClaw. It costs 12 tokens per session (4,749 once invoked), scanned A, original, Apache-2.0.

A Python workflow for analysing single-cell RNA sequencing data, which measures gene activity separately in individual cells. It covers quality checks, normalization, grouping similar cells, identifying cell types, and comparing conditions.

In plain words
What is it for?
Analysing 10X Chromium, Drop-seq, Smart-seq2, or inDrop data; combining batches; annotating cell types; and comparing conditions with multi-sample analysis.
Why use it?
It turns raw or processed sequencing files into interpretable cell populations and gene-expression results, including data combined from multiple batches.

Skill for Claude CodeCodex

Written for no agent in particular: nothing here depends on one.

Good fit Analysing 10X Chromium, Drop-seq, Smart-seq2, or inDrop data; combining batches; annotating cell types; and comparing conditions with multi-sample analysis.

Compare 6 skills from other repositories ↓
Install with agentmods
npx agentmods add skills/tiangzlab/omicsclaw/scrnaseq-scanpy-core-analysis
Install

Getting it into your agent

One page per mod, every tool's command on it. A separate URL per tool would split the same page into five that compete with each other.

Any agent
npx skills add TianGzlab/OmicsClaw --skill scrnaseq-scanpy-core-analysis
Clone the repo
git clone --depth 1 https://github.com/TianGzlab/OmicsClaw

Made for: Claude Code, Codex.

Wrote this? Show the measurements

A badge with what this costs and how it scanned, read live from this page, so it follows the numbers instead of freezing them. Markdown for a README, HTML for a documentation site or a project page.

agentmods badge for Single-Cell RNA-seq Core Analysis (Scanpy)

README.md
[![agentmods](https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/scrnaseq-scanpy-core-analysis/github.svg)](https://agentmods.dev/skills/tiangzlab/omicsclaw/scrnaseq-scanpy-core-analysis)
Your own site
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/scrnaseq-scanpy-core-analysis"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/scrnaseq-scanpy-core-analysis/github.svg" alt="Measured on agentmods" height="20"></a>

Or the 80×15 button, for a site that already has a row of RSS and ATOM ones. Only the verdict fits; the numbers stay here.

agentmods 80×15 button for Single-Cell RNA-seq Core Analysis (Scanpy)

Your own site · 80×15
<a href="https://agentmods.dev/skills/tiangzlab/omicsclaw/scrnaseq-scanpy-core-analysis"><img src="https://agentmods.dev/badge/skills/tiangzlab/omicsclaw/scrnaseq-scanpy-core-analysis.svg" alt="Reviewed on agentmods" width="80" height="20"></a>
Per session 12 Skills are progressive disclosure: only the name and description are preloaded; the body loads when the skill is used.
When invoked 4,749 The whole file, excluding the scripts and references it only reads on demand.
Security scan A 0 findings. A grade says what 26 rules found in the file — not that it is safe. Third-party audits
  • NVIDIA SkillSpector warn 7 Sept 2026
SkillSpector: 1 finding, up to medium

These are SkillSpector’s own severities. On a checked sample its high-severity flags on skills were ~96% false positives — a documented command, a public API, a “never do X” rule — so we show them as a caution to read, not a verdict. Why →

  • medium Excessive Agency · line 121
    Skill enables autonomous high-impact decisions without human-in-the-loop verification. Critical operations (destructive commands, financial transactions, data deletion) should require explicit user confirmation.
    Fix: Add human-in-the-loop confirmation for destructive, irreversible, or high-impact operations. Never auto-execute commands that modify files, send data, or alter system state.
How audits are shown
Origin original No closer match found in the catalogue.
Token cost

What it costs to keep this loaded

Counted locally with the o200k_base tokenizer, which is exact for GPT models; Claude uses its own tokenizer and its counts differ. Treat this as one consistent yardstick across the catalogue rather than a bill. Prices are per million input tokens.

ModelPer sessionOnce invoked
Fable 5.1 $0.00012 $0.04749
Opus 5 $0.00006 $0.02374
Sonnet 5 $0.00002 $0.00950
Haiku 4.5 $0.00001 $0.00475

Measured 10d ago against content hash 908a6527b90d, method: parsed. Prices are Anthropic first-party input rates as of 2026-09-09, from the pricing page.

Security

Grade A, and why

Single-Cell RNA-seq Core Analysis (Scanpy) scanned grade A with 0 findings against 26 rules in 11 categories — prompt injection, anti-refusal, data exfiltration, privilege escalation, supply chain, agent snooping, system-prompt leakage, SSRF and excessive agency — measured 10d ago.

The scan reads SKILL.md. This mod also ships 18 executable files (scripts/annotate_celltypes.py, scripts/cluster_cells.py, scripts/export_results.py, …), listed below but not scanned — reading those needs a real analyzer, not pattern matching.

A static scan of the body, not an audit. Every finding is printed with the line that produced it so you can judge whether it matters here. A mod is markdown that instructs an agent; that is exactly why what it instructs is worth reading.

Nothing flagged

None of the 26 patterns this scan looks for appear in this file: no shell pipes, no recursive deletes, no credential paths, no hidden text, no instruction-override or anti-refusal phrasing, no agent-config snooping. That is not a guarantee, it is the absence of the things that are checkable.

knowledge_base/scrnaseq-scanpy-core-analysis/SKILL.md · 290 lines

How it starts

The opening of the file, as written. The whole thing — 290 lines — stays where its author put it; the contents beside it link to each section on GitHub.

Single-Cell RNA-seq Core Analysis (Scanpy)

Complete workflow for single-cell RNA-seq analysis using Scanpy and the scverse ecosystem. Process raw data through quality control, normalization, clustering, and cell type annotation with publication-ready visualizations.

When to Use This Skill

  • Analyze 10X Chromium data (CellRanger output, H5 files, raw/filtered matrices)
  • Process Drop-seq, Smart-seq2, or inDrop single-cell RNA-seq data
  • Integrate multi-batch data using scVI, scANVI, or Harmony
  • Annotate cell types manually or with automated reference-based methods
  • Compare conditions using pseudobulk differential expression (multi-sample data)

Don't use for: Bulk RNA-seq (use bulk-rnaseq-counts-to-de-deseq2), R-based scRNA-seq (use scrnaseq-seurat-core-analysis), Spatial transcriptomics (coming soon)

Installation

Package Version License Commercial Use Installation
scanpy ≥1.9 BSD-3-Clause Permitted pip install scanpy
anndata ≥0.8 BSD-3-Clause Permitted pip install anndata
numpy ≥1.20 BSD-3-Clause Permitted pip install numpy
pandas ≥1.3 BSD-3-Clause Permitted pip install pandas
matplotlib ≥3.4 PSF Permitted pip install matplotlib
seaborn ≥0.12 BSD-3-Clause Permitted pip install seaborn
adjustText ≥0.8 MIT Permitted pip install adjustText
scrublet ≥0.2.3 MIT Permitted pip install scrublet
scvi-tools ≥1.0 BSD-3-Clause Permitted pip install scvi-tools
harmonypy ≥0.0.9 GPL-3 Permitted pip install harmonypy
celltypist ≥1.0 MIT Permitted pip install celltypist
pydeseq2 ≥0.4 MIT Permitted pip install pydeseq2

Install all: pip install scanpy anndata numpy pandas matplotlib seaborn adjustText scrublet

Minimum versions: Python ≥3.8, scanpy ≥1.9, anndata ≥0.8

Inputs

Required:

  • Raw or filtered count matrix: CellRanger output (filtered_feature_bc_matrix/), H5 files (.h5), AnnData (.h5ad), or count matrices (CSV/TSV)

Read the full file on GitHub · 290 lines

Changes

What this file has done since we first saw it

Hashed on every crawl. A supply-chain change to an agent config is a question of when, not whether, so the history is kept rather than the latest state alone.

  1. 10d ago First seen · 290 lines · 12 tokens per session scan A 908a6527b90d

Subscribe to this mod's changes

Single-Cell RNA-seq Core Analysis (Scanpy) is a skill published in the GitHub repository TianGzlab/OmicsClaw (160 stars, last pushed 1mo ago), licensed Apache-2.0. It adds 12 tokens to every session and 4,749 once invoked, about $0.0001 per session on Opus 5. A static security scan graded it A with 0 findings. No closer match exists in the catalogue, so it is treated as the original; first seen 2026-08-30.

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