Reason about clinical data terminology standards — MedDRA hierarchy (LLT→PT→HLT→HLGT→SOC), ICD-10 code structure and grouping, SNOMED CT concept model, LOINC panel relationships, and mapping decisions between systems. Use when the user asks to code adverse events, map diagnoses to ICD-10, choose a coding granularity…
Reason about drug repurposing strategies in HCLS — choosing between target-based and phenotype-based approaches, evaluating mechanism-of-action overlap, querying drug-gene interaction databases, assessing clinical translatability, and ranking candidates by evidence strength. Use when the user asks to repurpose a drug…
Reason about germline and somatic variant classification using ACMG/AMP 2015 and AMP/ASCO/CAP frameworks. Use when the user asks to classify a variant, interpret a VCF annotation, resolve a VUS, apply ACMG criteria, weigh ClinVar evidence, evaluate gnomAD allele frequencies, interpret REVEL/CADD/SpliceAI scores…